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The Critical Progress on Biomimic Scaffold for Engineered 3D Cardiac Anisotropy from Baolin Guo’s Research Group in FIST
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Myocardial infarction or heart attack is one of the major causes of death associated with cardiovascular disease. Tissue engineering strategies have been demonstrated as a potential approach for cardiac tissues regeneration.Mimicking the anisotropic structure of native cardiac tissue and guiding 3D cellular orientation and organization play a critical role in designing tissue engineering scaffolds for cardiac tissue regeneration. However, it remains an ongoing challenge to develop a well-defined scaffold that can guide cardiomyocytes (CMs) alignment and elongation within a 3D environment and further mimic the highly organized anisotropic structure of myocardium for cardiac tissue engineering.
Recently, Prof. Baolin Guo’s research group in FIST (Xi’an Jiaotong University) present a 3D biomimic scaffold based on aligned conductive nanofiber yarns network (NFYs-NET) within a hydrogel shell for mimicking the native cardiac tissue structure, and further demonstrate their great potential for engineering 3D cardiac anisotropy. The NFYs-NET structures are shown to control cellular orientation and enhance CMs maturation. 3D hybrid scaffolds were then fabricated by encapsulating NFYs-NET layers within hydrogel shell, and these 3D scaffolds performed the ability to promote aligned and elongated CMs maturation on each layer and individually control cellular orientation on different layers in a 3D environment. Furthermore, endothelialized myocardium was constructed by using this hybrid strategy via the co-culture of CMs on NFYs-NET layer and endothelial cells within hydrogel shell. These data indicated that these 3D hybrid scaffolds, containing NFYs-NET layer inducing cellular orientation, maturation and anisotropy and hydrogel shell providing a suitable 3D environment for endothelialization, show the great potential in engineering 3D cardiac anisotropy.
The research results were published in ACS Nano (IF = 13.942), one of the top international journals in nanoscience, titled with “Interwoven Aligned Conductive Nanofiber Yarn/Hydrogel Composite Scaffolds for Engineered 3D Cardiac Anisotropy”. PhD student Yaobin Wu and Ling Wang from FIST were the co-first authors of this paper, and Xi'an Jiaotong University was the correspondent unit.
National Natural Science Foundation of China and Xi’an Jiaotong University’s financial support were acknowledged.
Professor Baolin Guo’s group engages in the research of biomedical polymer materials, such as biodegradable hydrogels, biodegradable conductive polymer materials, the preparation of biodegradable porous polymer scaffolds, drug controlled release system and etc. Welcome students from relevant departments.
Homepage of Baolin Guo’s research group: http://gr.xjtu.edu.cn/web/baoling
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